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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

Fig. 1

Identifications of double hit and triple hit in DLBCL and BL cell lines by FISH. MYC, BCL2, and BCL-6 rearrangements were detected by FISH using break-apart probes carried out in DLBCL cell lines (n = 9) and BL cell line (n = 2). Representative images of c-MYC, BCL-2, and BCL-6 FISH in DLBCL and BL cell lines are shown. Images of U2932 (a-c) indicate a normal 2-fusion (f) signal pattern for MYC, amplification of BCL-2, and 4F for BCL6. LY1 MYC 1R1ampR2F, BCL-2 3R2G, and BCL-6 3F (d-f). VAL MYC 3R1G2F, BCL-2 3R1G1F, and BCL-6 1R1G1F (g-i). LY3 MYC 3F, BCL-2 1R1G1F, and BCL-6 1R2F (j-l). Raji MYC 1R1G1F, BCL-2 3F, and BCL-6 2F (m-o)

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