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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

Fig. 4

MYC and BCL-6 transcription is regulated by BET bromodomain protein in DHL/THL cells. a, b DHL and THL cell lines were treated with BET bromodomain inhibitors I-BET, JQ1, and OTX, and RT-PCR was performed using MYC- and BCL-6-specific primers. c, d ChIP assay was performed in the I-BET-treated DHL (LY1) and THL (Val) cells using BRD4 antibody, and RT-PCR was performed using MYC promoter primers. Experiments were repeated three times and a representative image is shown

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