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Fig. 6 | Journal of Hematology & Oncology

Fig. 6

From: Targeting MYC activity in double-hit lymphoma with MYC and BCL2 and/or BCL6 rearrangements with epigenetic bromodomain inhibitors

Fig. 6

Effect of I-BET and JQ1 on cell surface expression of CD47 and PD-L1 on WT, DHL and THL cells. a Cells (0.5 × 106) from wild-type MYC (U2932), double-hit (DOHH2), and triple-hit (Val) B cell lines were harvested, and PD-L1 expression was determined by flow cytometry. b Val (0.5 × 106) cells were treated with I-BET (10 μM), JQ1 (10 μM), or DMSO control. After 24 h, cells were harvested and the effects on PD-L1 were investigated by flow cytometry. c Cells (0.5 × 106) from U2932, DOHH2, and Val were treated with JQ1 (10 μM) or DMSO control. After 24 h, cells were harvested and CD47 expression was determined by flow cytometry

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