|  | Total | PD-L1− | PD-L1+ | P value | CD8+ TIL high | CD8+ TIL low | P value | TMB high | TMB low | P value | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
 |  | N | N | % | N | % | N | % | N | % | N | % | N | % | |||
Age | < 65 | 105 | 72 | 68.57 | 33 | 31.43 | 0.011 | 82 | 78.10 | 23 | 21.90 | 0.113 | 53 | 50.48 | 52 | 49.52 | 0.948 |
≥ 65 | 84 | 71 | 84.52 | 13 | 15.48 |  | 57 | 67.86 | 27 | 32.14 |  | 42 | 50.00 | 42 | 50.00 |  | |
Sex | Male | 179 | 134 | 74.86 | 45 | 25.14 | 0.480 | 131 | 73.18 | 48 | 26.82 | 0.915 | 91 | 50.84 | 88 | 49.16 | 0.732 |
Female | 10 | 9 | 90.00 | 1 | 10.00 | Â | 8 | 80.00 | 2 | 20.00 | Â | 4 | 40.00 | 6 | 60.00 | Â | |
Smoking | Never | 60 | 49 | 81.67 | 11 | 18.33 | 0.190 | 47 | 78.33 | 13 | 21.67 | 0.309 | 25 | 41.67 | 35 | 58.33 | 0.107 |
Current/former | 129 | 94 | 72.87 | 35 | 27.13 | Â | 92 | 71.32 | 37 | 28.68 | Â | 70 | 54.26 | 59 | 45.74 | Â | |
ECOG PS | 0 | 140 | 104 | 74.29 | 36 | 25.71 | 0.456 | 105 | 75.00 | 35 | 25.00 | 0.443 | 63 | 45.00 | 77 | 55.00 | 0.014 |
1 | 49 | 39 | 79.59 | 10 | 20.41 | Â | 34 | 69.39 | 15 | 30.61 | Â | 32 | 65.31 | 17 | 34.69 | Â | |
p-Stage | I | 92 | 72 | 78.26 | 20 | 21.74 | 0.417 | 66 | 71.74 | 26 | 28.26 | 0.584 | 45 | 48.91 | 47 | 51.09 | 0.24 |
II | 54 | 41 | 75.93 | 13 | 24.07 | Â | 42 | 77.78 | 12 | 22.22 | Â | 25 | 46.30 | 29 | 53.70 | Â | |
III | 43 | 30 | 69.77 | 13 | 30.23 | Â | 31 | 72.09 | 12 | 27.91 | Â | 25 | 58.14 | 18 | 41.86 | Â | |
Pleural invasion | Yes | 14 | 13 | 92.86 | 1 | 7.14 | 0.217 | 10 | 71.43 | 4 | 28.57 | 0.898 | 6 | 42.86 | 8 | 57.14 | 0.565 |
No | 175 | 130 | 74.29 | 45 | 25.71 | Â | 129 | 73.71 | 46 | 26.29 | Â | 89 | 50.86 | 86 | 49.14 | Â | |
Vascular invasion | Yes | 9 | 6 | 66.67 | 3 | 33.33 | 0.805 | 6 | 66.67 | 3 | 33.33 | 0.927 | 6 | 66.67 | 3 | 33.33 | 0.505 |
No | 180 | 137 | 76.11 | 43 | 23.89 | Â | 133 | 73.89 | 47 | 26.11 | Â | 89 | 49.44 | 91 | 50.56 | Â | |
Differentiation | High | 10 | 7 | 70.00 | 3 | 30.00 | 0.960 | 7 | 70.00 | 3 | 30.00 | 0.915 | 4 | 40.00 | 6 | 60.00 | 0.732 |
Intermediate | 124 | 93 | 75.00 | 31 | 25.00 | Â | 92 | 74.19 | 32 | 25.81 | Â | 63 | 50.81 | 61 | 49.19 | Â | |
Low | 55 | 43 | 78.18 | 12 | 21.82 | Â | 40 | 72.73 | 15 | 27.27 | Â | 28 | 50.91 | 27 | 49.09 | Â |