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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: K+-Cl cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells

Fig. 1

Structure of KCC1 and classification of the CCC family. a Structure. The topology model shown was drawn with the program PLOT by Biff Forbush (Yale University). Branched lines correspond to glycosylation sites, other symbols to residues and colors other than blue, to functional sites of potential importance. b Phylogenetic tree of the CCC family. The phylogram shown was obtained with the programs PhyML v3.1/3.0 aLRT and MUSCLE v3.8.31 [36, 37] using the most abundant human variants. GenBank accession numbers are provided in footnote 1Footnote

Sequences used to generate the phylogram of Fig. 1b:

  • CCC Accession numbers

  • NKCC1 NP_001037.1

  • NKCC2 NP_000329.2

  • NCC NP_000330.2

  • KCC1 NP_005063.1

  • KCC2 NP_001128243.1

  • KCC3 NP_598408.1

  • KCC4 NP_006589.2

  • CCC8 NP_064631.2

  • CCC9 NP_078904.3

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