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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: K+-Cl− cotransporter 1 (KCC1): a housekeeping membrane protein that plays key supplemental roles in hematopoietic and cancer cells

Fig. 2

Regulation of K+-Cl− cotransport in HbS cells. During occlusive crises, PGIF are produced from ischemic non-erythroid tissues and taken up by RTC where it could increase KCC1 expression and overcome the potential inhibitory effect of low pO2i on K+-Cl− cotransport. Abbreviations: HbS, hemoglobin S; HIF, hypoxia-induced factor; PIGF, placental growth factor

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Journal of Hematology & Oncology

ISSN: 1756-8722

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