Fig. 4

Glyphosate led to multiple organ dysfunction. a Histological evaluation of bone morphology from 4 groups of mice. Bone lytic lesions (indicated by arrows) were detected in the femoral shaft of Vk*MYC mice treated with glyphosate. Scale bar = 500 μm (top) or 100 μm (bottom). b Infiltrating plasma cells in the bone marrow of glyphosate-treated mice. Scale bar = 20 μm. Arrows pointed to plasma cells. c Infiltrating plasma cells in the spleen of glyphosate-treated mice. Scale bar = 20 μm. Arrows point to plasma cells. d Collagen deposition in the liver was observed in glyphosate-treated Vk*MYC mice. n = 10 mice per group. Scale bar = 500 μm (top) or 200 μm (bottom). e Destruction of lung morphology was observed in glyphosate-treated Vk*MYC mice. n = 10 mice per group. Scale bar = 500 μm. f Protein deposition (indicated by arrows) in the kidney was observed in glyphosate-treated Vk*MYC mice. n = 10 mice per group. Scale bar = 500 μm. All panels show 1 representative image each from 4 groups of mice unless otherwise indicated