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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Dual inhibition of IGF-IR and ALK as an effective strategy to eradicate NPM-ALK+ T-cell lymphoma

Fig. 2

Combined treatment with PPP and ASP3026 decreases significantly the proliferation of NPM-ALK+ T cell lymphoma cells. Compared with control untreated lymphoma cells, treatment with a low concentration of PPP (0.25 μM) or ASP3026 (1.0 μM) alone for 24 h decreased cell proliferation in Karpas 299, SR-786, and DEL cells. Importantly, the combination treatment decreased cell proliferation more significantly than the effects of a single agent alone. Similar effects, yet more pronounced, were noted after 48 h. Results are shown as means ± SD of three independent experiments

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