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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Protein arginine methyltransferase 3-induced metabolic reprogramming is a vulnerable target of pancreatic cancer

Fig. 1

High PRMT3 expression is an unfavorable prognostic factor in pancreatic cancer patients. a The PRMT3 protein level in different human pancreatic cancer cell lines was determined by western blotting. b The PRMT3 protein levels were compared in adjacent normal and tumor parts of pancreatic tumors. The intensity of the bands was quantified by ImageJ and normalized to that of actin. The statistical graph was presented. Error bars, SEM. Normal tissues, n = 4; tumor tissues, n = 16. *p < 0.05. c Representative IHC staining of PRMT3 protein in human PDAC tissue. d The correlation between PRMT3 expression and pancreatic cancer patient survival in a TCGA cohort (https://www.proteinatlas.org/ENSG00000185238-PRMT3/pathology/ tissue/pancreatic+cancer). p < 0.001. e A box-and-whisker plot of PRMT3 gene expression in pancreatic tumors from the Oncomine dataset. The box-and-whisker 1, 2, and 3 respectively indicates pathology grade 1 (n = 9), grade 2 (n = 27), and grade 3 (n = 10). The correlation between PRMT3 gene expression and pathology grades was statistically significant

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