Fig. 4

Overexpression of PRMT3 induces metabolic reprogramming. a Principal component analysis of the metabolites in GFP- and GFP-PRMT3-overexpressing PANC-1 cells. The expression levels of GFP and GFP-PRMT3 were detected by western blotting. b Hierarchical cluster analysis (HCA) of the metabolites in GFP- and GFP-PRMT3-overexpressing PANC-1 cells. The horizontal axis and vertical axis show sample names and peaks. c Change of the metabolites in central carbon metabolism. The bars/lines represent relative areas of each metabolite in GFP- (blue) and GFP-PRMT3 (red)-overexpressing PANC-1 cells, respectively. N.D., not detected. d Change of the metabolites in lipid and amino acid metabolism. The bars/lines represent relative areas of each metabolite in GFP- (blue) and GFP-PRMT3 (red)-overexpressing PANC-1 cells, respectively. N.D., not detected