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Fig. 4 | Journal of Hematology & Oncology

Fig. 4

From: LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis

Fig. 4

LINC01123 promotes tumor growth and aerobic glycolysis in vivo. a A549 cell treated with sh-NC lentivirus were inoculated subcutaneously into the left flanks and treated with sh-1123 lentivirus into the right flanks of nude mice (n = 5). Tumor growth curves showed that sh-1123 group suppressed tumor growth compared with sh-NC group. b 18F-FDG micro-PET/CT images of living nude mice were conducted 3 weeks after injection. Images showed obvious FDG uptake in sh-NC xenografts, while mild FDG uptake in sh-1123 xenografts. c The xenografts were subjected to H&E and IHC staining with Ki-67 and c-Myc. Scale bar = 50 μm (× 400). Data shown are mean ± SD (n = 3). (*P < 0.05, **P < 0.01, ***P < 0.001)

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