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Fig. 7 | Journal of Hematology & Oncology

Fig. 7

From: LINC01123, a c-Myc-activated long non-coding RNA, promotes proliferation and aerobic glycolysis of non-small cell lung cancer through miR-199a-5p/c-Myc axis

Fig. 7

LINC01123 functions as an oncogene via miR-199a-5p and c-Myc. a Colony formation rescue experiment showed that cell proliferation reduced by si-1123 could be increased by miR-199a-5p inhibitor or Myc-OE in H1299 cell. b Colony formation rescue experiment showed that cell proliferation stimulated by ectopic expression of LINC01123 could be repressed by miR-199a-5p mimics or si-Myc in A549 cell. ce Metabolic functional rescue experiment showed that 18F-FDG uptake, lactate production, and protein expression level of HK2 and LDHA reduced by si-1123 could be increased by miR-199a-5p inhibitor or Myc-OE in H1299 cell. fh Metabolic functional rescue experiment showed that 18F-FDG uptake, lactate production, and protein expression level of HK2 and LDHA promoted by ectopic expression of LINC01123 could be repressed by miR-199a-5p mimics or si-Myc in A549 cell. Scale bar = 100 μm. Data shown are mean ± SD (n = 3) (*P < 0.05, **P < 0.01, ***P < 0.001)

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