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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: CircRNAs in cancer metabolism: a review

Fig. 2

circRNAs and the Warburg effect associated signaling pathways. This figure indicates the effects of circRNAs on the Warburg effect-associated signaling pathways. The PI3K/Akt pathway promotes GLUT1, HK2, and PFK2. The alteration of RAS pathway upregulates GLUT1 and glycolytic enzymes. The STAT3 pathway gives rise to HK2. And the Wnt/β-catenin pathway upregulates the transcription of MCT1 and PDK1. In these four pathways, most circRNAs work as ceRNAs to affect the Warburg effect. The circRNAs in the dark blue rounded rectangle are considered to function in cancer cells, while the circRNAs in the light blue rounded rectangle are just proved to function in normal cells. miRNAs are in the green rectangle; the components of the PI3K/Akt pathway are in the pink circle; the components of the RAS pathway are in the orange circle; the components of the STAT3 pathway are in the green circle; the components of the Wnt/β-catenin pathway are in the yellow circle. The positive relationships are shown by arrows, and the negative relationships are shown by short dashes. BLC, bladder cancer; CRC, colorectal cancer; GC, gastric cancer; OS, osteosarcoma; OSCC, oral squamous cell carcinoma ; PTC, papillary thyroid cancer

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