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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Long noncoding RNA GSTM3TV2 upregulates LAT2 and OLR1 by competitively sponging let-7 to promote gemcitabine resistance in pancreatic cancer

Fig. 5

GSTM3TV2 upregulates LAT2 and OLR1 expression. a The expression levels of LAT2, OLR1 and PARM1 were significantly upregulated in gemcitabine-resistant AsPC-1/GR and MIAPaCa-2/GR cells than in AsPC-1 and MIAPaCa-2 cells as detected by qRT-PCR analysis. b The expression levels of LAT2 and OLR1 were significantly increased when GSTM3TV2 overexpresses in AsPC-1 and MIAPaCa-2 cells as detected by qRT-PCR analysis. c The expression levels of LAT2 and OLR1 were significantly decreased when GSTM3TV2 knock down in AsPC-1/GR and MIAPaCa-2/GR cells as detected by qRT-PCR analysis. d Western blot analysis shown that LAT2 and OLR1 were upregulated when GSTM3TV2 overexpresses in AsPC-1 and MIAPaCa-2 cells; whereas, LAT2 and OLR1 were downregulated when GSTM3TV2 knock down in AsPC-1/GR and MIAPaCa-2/GR cells. The data are presented as the mean ± SD (Student’s t test; asterisk indicates P < 0.05)

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