Fig. 7

GSTM3TV2 promotes gemcitabine resistance dependent on the expression of LAT2 and OLR1. a Overexpression of let-7 in MIAPaCa-2/GR cells increased the inhibitory effects of gemcitabine as determined by detecting cell viability. b Overexpression of let-7 in Rv-AsPC-1-GSTM3TV2 cells increased the inhibitory effects of gemcitabine as determined by detecting cell viability. c Overexpression of let-7 in MIAPaCa-2/GR cells increased gemcitabine-induced cell death as determined by detecting apoptosis rates. d Overexpression of let-7 in Rv-AsPC-1-GSTM3TV2 cells increased gemcitabine-induced cell death as determined by detecting apoptosis rates. e Knockdown LAT2 and OLR1 in MIAPaCa-2/GR cells increased the inhibitory effects of gemcitabine as determined by detecting cell viability. f Knockdown LAT2 and OLR1 in MIAPaCa-2/GR cells increased gemcitabine-induced cell death as determined by detecting apoptosis rates. g Knockdown LAT2 and OLR1 in Rv-AsPC-1-GSTM3TV2 cells increased the inhibitory effects of gemcitabine as determined by detecting cell viability. h Knockdown LAT2 and OLR1 in Rv-AsPC-1-GSTM3TV2 cells increased gemcitabine-induced cell death as determined by detecting apoptosis rates. i, j Western blot analysis showed that the expression levels of LAT2 and OLR1 were downregulated when let-7 overexpresses in MIAPaCa-2/GR and Rv-AsPC-1-GSTM3TV2 cells