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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: TCR-like antibodies in cancer immunotherapy

Fig. 2

The molecular mechanisms of TCR-like antibodies against tumor cells. TCR-like antibodies mediate their anti-tumor effects through multiple mechanisms. (a) Conjugation with fluorescent reagents to detect the expression of the peptide/MHC complex on the surface of tumor cells. (b) Antibody-dependent cell-mediated cytotoxicity (ADCC) with NK cells. (c) Complement-dependent cytotoxicity (CDC) with complements. (d) Antibody-dependent cellular phagocytosis (ADCP) with microphages. (e) Direct induction of tumor cell apoptosis. (f) Conjugation with drugs or toxins. (g) Conjugation as a bi-specific T cell engager (BiTE). (h) CAR-T strategy. TCR-like: T cell receptor-like; MHC: major histocompatibility complex; MAC: membrane attack complex; FcγR: Fc gamma receptor; FcγR IIα: Fc gamma receptor II alpha

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