Antigen | Epitope sequence | MHC allele | Diseases targeted | Function | TCR-like antibody format | Clone | Generation strategy | Reference |
---|---|---|---|---|---|---|---|---|
MAGE1 | EADPTGHSY | HLA-A*0101 | Melanoma | Detection | Fab | Fab-G8 | Phage | [20] |
EADPTGHSY | HLA-A*0101 | Melanoma | CAR-T | Fab | Fab-G8 | Phage | [21] | |
EADPTGHSY | HLA-A*0101 | Melanoma | CAR-T | Fab | Fab-G8/Fab-Hyb3 | Phage | [22] | |
GP100 | KTWGQYWQV | HLA-A*0201 | Melanoma | Detection | Fab | G2D12, G3G4 | Phage | |
IMDQVPFSV | HLA-A*0201 | Melanoma | Detection | Fab | 1A9, 1C8, 1A11, 1A7 | Phage | ||
YLEPGPVTV/A | HLA-A*0201 | Melanoma | detection/inhibition | Fab | 2F1, 2B2, 2C5, 2D1 | Phage | ||
IMDQVPFSV | HLA-A*0201 | Melanoma | Immunotoxin | scFv-PE38 | G1 | Phage | [16] | |
ITDQVPFSV | HLA-A*0201 | Melanoma | CAR-T | sdAb-CAR | GPA7 | Phage | [25] | |
LLLTVLTVL | HLA-A*0201 | Melanoma | Immunotoxin | Fab | 2F1-PE38KDEL | Phage | [26] | |
hTERT | ILAKFLHWL | HLA-A*0201 | Melanoma, prostate cancer | Detection/inhibition | Fab | 4A9, 4G9 | Phage | [27] |
RLVDDFLLV | HLA-A*0201 | Melanoma, prostate cancer | Detection/inhibition | Fab | 3H2, 3G3 | Phage | [27] | |
MUC1 | LLLTVLTVV | HLA-A*0201 | Breast cancer | Detection | Fab | M2B1, M2F5, M3A1, M3B8, M3C8 | Phage | [28] |
NY-ESO-1 | SLIMWITQC | HLA-A*0201 | Melanoma | Detection/inhibition | Fab | 3M4E5;3M4F4;T1 | Phage | [29] |
MAGE3 | FLWGPRALV | HLA-A*0201 | Melanoma | Detection | mIgG1 | 7D4, 8A11, 2G12, 9E6 | Hybridoma | [30] |
hCGβ | GVLPALPQV | HLA-A*0201 | Ovarian, colon, breast cancer | CDC, ADCC, direct | mIgG2a | RL4B/3.2G1 | Hybridoma | [31] |
GVLPALPQV | HLA-A*0201 | Ovarian, colon, breast cancer | Detection | IgG1 | 1B10 | Hybridoma | [21] | |
TMTRVLQGV | HLA-A*0201 | Ovarian, colon, breast cancer | Detection | IgG1 | 3F9 | Hybridoma | [32] | |
Her2/Neu | KIFGSLAFL | HLA-A*0201 | Breast, colon cancer | Detection/inhibition | IgG1 | 1B8 | Hybridoma | [33] |
Melan-A/MART-1 | EAAGIGILTV | HLA-A*0201 | Melanoma | Detection | Fab | 2M3F11;3N4E9;2N4B4;E6;H4 | Phage | [34] |
EAAGIGILTV | HLA-A*0201 | Melanoma | Immunotoxin | Fab-PE38 | CAG10, CLA12 | Phage | [26] | |
TARP | FLRNFSLML | HLA-A*0201 | Breast, prostate cancer | Immunotoxin | Fab-PE38 | Fab-D2 | Phage | [35] |
p53 | RMPEAAPPV | HLA-A*0201 | Various tumors, breast cancer | ADCC, ADCP, CDC | IgG1 | T1-116C | Hybridoma | [36] |
RMPEAAPPV | HLA-A*0201 | – | Detection | IgG1, IgG2b | T1-29D, T1-84C | Hybridoma | [37] | |
GLAPPQHLIRV | HLA-A*0201 | – | Detection | IgG1, IgG2a, IgG1 | T2-108A, T2-2A, T2-116A | Hybridoma | [37] | |
Tyrosinase | YMDGTMSQV | HLA-A*0201 | Melanoma | Detection | Fab | TA2 | Phage | [38] |
p68 | YLLPAIVHI | HLA-A*0201 | Breast cancer | ADCP/direct | mIgG2a | RL6A | Hybridoma | [39] |
MIF | FLSELTQQL | HLA-A*0201 | Breast cancer | CDC, ADCC, direct | IgG2a | RL21A | Hybridoma | [40] |
Proteinase 3 | VLQELNVTV | HLA-A*0201 | AML | CDC, CAR-T | IgG2a | 8F4 | Hybridoma | |
WT1 | RMFPNAPYL | HLA-A*0201 | Leukemia, ovarian, colon cancer | ADCC, ADCP | hIgG1 | ESK1 | Phage | [15] |
RMFPNAPYL | HLA-A*0201 | Leukemia | CAR-T | Fab | F2, F3 | Phage | [43] | |
RMFPNAPYL | HLA-A*0201 | Leukemia | ADCC, CAR-T | scFv | Clone45 | Phage | [44] | |
HA-1H | VLHDDLLEA | HLA-A*0201 | Leukemia | CAR-T | scFv, scFv-CAR | #131 | Phage | [11] |
PRAME | ALYVDSLFFL | HLA-A*0201 | Leukemia, lymphoma | ADCC, CDC, ADCP | hIgG1 | Pr20 | Phage | [45] |
HTLV-1(TAX-11) | LLFGYPVYV | HLA-A*0201 | T-Cell leukemia/lymphoma | Detection | Fab | T3A4,T3D4;T3F2;T3E3;T3D3;T2H9 | Phage | |
Influenza(M1-58) | GILGFVFTL | HLA-A*0201 | Flu | Detection | Fab | M1-D1,M1-G8;M1-D12;M1-A2 | Phage | [48] |
HBV (ENV-183) | FLLTRILTI | HLA-A*0201 | Hepatitis B | Detection/intracellular delivery of cargo | mIgG1 | N/A | Hybridoma | [49] |
HIV-1 (Nef-105) | RRQDILWIY | HLA-C*07 | AIDS | Surface co-expression with fas-ligand on virion particle | Fab | C3 | Phage | [50] |
HIV-1 (elf4G-720) | VLMTEDIKL | HLA-A*0201 | AIDS | Detection | mIgG1 | 4F7 | Hybridoma | [51] |
HIV-1 (Nef-138) | RYPLTFGWCF | HLA-A*2401 | AIDS | Detection | Fab | scFv#3, scFv#27 | Phage | [52] |
CMV (pp65-495) | NLVPMVATV | HLA-A*0201 | Mucoepidermoid carcinoma | Detection | Fab | H9 | Phage | [53] |