TCR-like antibodies in cancer immunotherapy

He, Qinghua; Liu, Zhaoyu; Liu, Zhihua; Lai, Yuxiong; Zhou, Xinke; Weng, Jinsheng

doi:10.1186/s13045-019-0788-4

Journal of Hematology & Oncology

Table 1 TCR-like antibodies in human diseases. Information of published TCR-like antibodies was collected from literature and reference [18] with the consent of the authors

From: TCR-like antibodies in cancer immunotherapy

Antigen	Epitope sequence	MHC allele	Diseases targeted	Function	TCR-like antibody format	Clone	Generation strategy	Reference
MAGE1	EADPTGHSY	HLA-A*0101	Melanoma	Detection	Fab	Fab-G8	Phage	[20]
	EADPTGHSY	HLA-A*0101	Melanoma	CAR-T	Fab	Fab-G8	Phage	[21]
	EADPTGHSY	HLA-A*0101	Melanoma	CAR-T	Fab	Fab-G8/Fab-Hyb3	Phage	[22]
GP100	KTWGQYWQV	HLA-A*0201	Melanoma	Detection	Fab	G2D12, G3G4	Phage	[23, 24]
	IMDQVPFSV	HLA-A*0201	Melanoma	Detection	Fab	1A9, 1C8, 1A11, 1A7	Phage	[23, 24]
	YLEPGPVTV/A	HLA-A*0201	Melanoma	detection/inhibition	Fab	2F1, 2B2, 2C5, 2D1	Phage	[23, 24]
	IMDQVPFSV	HLA-A*0201	Melanoma	Immunotoxin	scFv-PE38	G1	Phage	[16]
	ITDQVPFSV	HLA-A*0201	Melanoma	CAR-T	sdAb-CAR	GPA7	Phage	[25]
	LLLTVLTVL	HLA-A*0201	Melanoma	Immunotoxin	Fab	2F1-PE38KDEL	Phage	[26]
hTERT	ILAKFLHWL	HLA-A*0201	Melanoma, prostate cancer	Detection/inhibition	Fab	4A9, 4G9	Phage	[27]
hTERT	RLVDDFLLV	HLA-A*0201	Melanoma, prostate cancer	Detection/inhibition	Fab	3H2, 3G3	Phage	[27]
MUC1	LLLTVLTVV	HLA-A*0201	Breast cancer	Detection	Fab	M2B1, M2F5, M3A1, M3B8, M3C8	Phage	[28]
NY-ESO-1	SLIMWITQC	HLA-A*0201	Melanoma	Detection/inhibition	Fab	3M4E5;3M4F4;T1	Phage	[29]
MAGE3	FLWGPRALV	HLA-A*0201	Melanoma	Detection	mIgG1	7D4, 8A11, 2G12, 9E6	Hybridoma	[30]
hCGβ	GVLPALPQV	HLA-A*0201	Ovarian, colon, breast cancer	CDC, ADCC, direct	mIgG2a	RL4B/3.2G1	Hybridoma	[31]
	GVLPALPQV	HLA-A*0201	Ovarian, colon, breast cancer	Detection	IgG1	1B10	Hybridoma	[21]
	TMTRVLQGV	HLA-A*0201	Ovarian, colon, breast cancer	Detection	IgG1	3F9	Hybridoma	[32]
Her2/Neu	KIFGSLAFL	HLA-A*0201	Breast, colon cancer	Detection/inhibition	IgG1	1B8	Hybridoma	[33]
Melan-A/MART-1	EAAGIGILTV	HLA-A*0201	Melanoma	Detection	Fab	2M3F11;3N4E9;2N4B4;E6;H4	Phage	[34]
Melan-A/MART-1	EAAGIGILTV	HLA-A*0201	Melanoma	Immunotoxin	Fab-PE38	CAG10, CLA12	Phage	[26]
TARP	FLRNFSLML	HLA-A*0201	Breast, prostate cancer	Immunotoxin	Fab-PE38	Fab-D2	Phage	[35]
p53	RMPEAAPPV	HLA-A*0201	Various tumors, breast cancer	ADCC, ADCP, CDC	IgG1	T1-116C	Hybridoma	[36]
	RMPEAAPPV	HLA-A*0201	–	Detection	IgG1, IgG2b	T1-29D, T1-84C	Hybridoma	[37]
	GLAPPQHLIRV	HLA-A*0201	–	Detection	IgG1, IgG2a, IgG1	T2-108A, T2-2A, T2-116A	Hybridoma	[37]
Tyrosinase	YMDGTMSQV	HLA-A*0201	Melanoma	Detection	Fab	TA2	Phage	[38]
p68	YLLPAIVHI	HLA-A*0201	Breast cancer	ADCP/direct	mIgG2a	RL6A	Hybridoma	[39]
MIF	FLSELTQQL	HLA-A*0201	Breast cancer	CDC, ADCC, direct	IgG2a	RL21A	Hybridoma	[40]
Proteinase 3	VLQELNVTV	HLA-A*0201	AML	CDC, CAR-T	IgG2a	8F4	Hybridoma	[41, 42]
WT1	RMFPNAPYL	HLA-A*0201	Leukemia, ovarian, colon cancer	ADCC, ADCP	hIgG1	ESK1	Phage	[15]
	RMFPNAPYL	HLA-A*0201	Leukemia	CAR-T	Fab	F2, F3	Phage	[43]
	RMFPNAPYL	HLA-A*0201	Leukemia	ADCC, CAR-T	scFv	Clone45	Phage	[44]
HA-1H	VLHDDLLEA	HLA-A*0201	Leukemia	CAR-T	scFv, scFv-CAR	#131	Phage	[11]
PRAME	ALYVDSLFFL	HLA-A*0201	Leukemia, lymphoma	ADCC, CDC, ADCP	hIgG1	Pr20	Phage	[45]
HTLV-1(TAX-11)	LLFGYPVYV	HLA-A*0201	T-Cell leukemia/lymphoma	Detection	Fab	T3A4,T3D4;T3F2;T3E3;T3D3;T2H9	Phage	[46, 47]
Influenza(M1-58)	GILGFVFTL	HLA-A*0201	Flu	Detection	Fab	M1-D1,M1-G8;M1-D12;M1-A2	Phage	[48]
HBV (ENV-183)	FLLTRILTI	HLA-A*0201	Hepatitis B	Detection/intracellular delivery of cargo	mIgG1	N/A	Hybridoma	[49]
HIV-1 (Nef-105)	RRQDILWIY	HLA-C*07	AIDS	Surface co-expression with fas-ligand on virion particle	Fab	C3	Phage	[50]
HIV-1 (elf4G-720)	VLMTEDIKL	HLA-A*0201	AIDS	Detection	mIgG1	4F7	Hybridoma	[51]
HIV-1 (Nef-138)	RYPLTFGWCF	HLA-A*2401	AIDS	Detection	Fab	scFv#3, scFv#27	Phage	[52]
CMV (pp65-495)	NLVPMVATV	HLA-A*0201	Mucoepidermoid carcinoma	Detection	Fab	H9	Phage	[53]

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