Fig. 8From: RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemiaSchematic presentation of the crucial role of RUNX1-MT in the leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia. Co-expression of ASXL1-R693X and RUNX1-R135T increased HIF1-α activity and its target gene, ID1 expression, enhancing cell proliferation, blocking differentiation, and promoting leukemogenesisBack to article page