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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Correction to: Oroxylin A promotes PTEN-mediated negative regulation of MDM2 transcription via SIRT3-mediated deacetylation to stabilize p53 and inhibit glycolysis in wt-p53 cancer cells

Fig. 2

Oroxylin A downregulates the protein and mRNA expression of p53-related glycolytic pathway components. (a) MCF-7 and HCT116 cells were treated with oroxylin A (100 and 200 μM) for 48 h. Western blot assays were performed for the p53-targeted gene products p53, TIGAR, PGM, and GLUT4. (d) MCF-7 and HCT116 were transfected with siRNA targeting wt-p53 or with a non-targeting control siRNA, then incubated with 200 μM oroxylin A for 48 h. Western blot assays were performed for the p53-targeted gene products TIGAR, PGM, and GLUT4. All the Western Blot bands were quantified. Bars, SD;*p<0.05 or **p<0.01 versus non-treated control

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