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Table 1 Characterization of the study population and the CSF parameters

From: APRIL and BAFF: novel biomarkers for central nervous system lymphoma

Diagnosis Patient characteristics CSF parameters
N Age Sex (F/M) Cells/μl Atypical cells in x/N Protein (mg/dl) Glucose (mg/dl) Albumin index CSF/serum [× 10−3]
Newly diagnosed PCNSL 30 70 (21–89) 13/17 7 (1–408) 8/30 67 (9–604) 64 (10–93) 10 (4–96)
Newly diagnosed SCNSL 7 66 (53–90) 2/5 9 (2–369) 1/7 73 (50–221) 54 (34–103) 13 (8–53)
Relapsed PCNSL 16 63 (23–84) 5/11 7 (1–202) 4/16 81 (38–448) 66 (12–99) 12 (3–65)
PCNSL complete remission 21 63 (27–78) 9/12 1 (0–8) 0/21 53 (21–106) 64 (51–88) 8 (2–49)
Primary brain tumor (PBT) 21 58 (21–83) 6/15 2 (0–204) 1/21 58 (25–160) 59 (53–89) 8 (2–22)
Metastatic brain tumor (MBT) 13 68 (31–77) 7/8 4 (0–80) 7/13 47 (15–191) 66 (45–98) 6 (4–13)
Autoimmune inflammatory disease (AID) 26 43 (19–72) 16/10 7 (0–144) 0/26 54 (24–116) 61 (51–101) 7 (2–19)
Neuroinfectious disease (NID) 3 47 (40–49) 1/2 7 (2–51) 0/3 66 (39–147) 56 (56–57) 13 (5–14)
Other neurologic disease (OND) 30 47 (18–85) 16/14 1 (0–3) 0/30 39 (22–83) 63 (47–91) 4 (3–12)
  1. Abbreviations: N number, F female, M male. Data are presented as median (range). Detailed patient characteristics: 30 newly diagnosed PCNSL, all DLBCL; 27 diagnosed via histopathological confirmation, 3 diagnosed with flow cytometry and immunophenotyping. Twenty-seven immunocompetent, 3 human immunodeficiency virus (HIV) associated. Seven newly diagnosed SCNSL: 6 DLCBL, 1 marginal zone B cell lymphoma; all immunocompetent. Sixteen relapsed PCNSL: all DLBCL; all immunocompetent. Twenty-one primary brain tumors: 8 glioblastoma multiforme, 7 astrocytoma, 1 oligodendroglioma, 1 ependymoma, and 4 medulloblastoma. Thirteen metastatic brain tumors: 3 breast cancer, 3 lung cancer, 5 malignant melanoma, and 2 metastasis of unknown primary; 5 of these 13 patients were diagnosed with concomitant meningeosis neoplastica. Twenty-six autoimmune-inflammatory disease: 16 multiple sclerosis or clinically isolated syndrome at manifestation, 2 neuromyelitis optica, 3 acute disseminated encephalomyelitis, and 5 with stereotactic brain biopsy-proven autoimmune inflammation of unknown classification. Three neuroinfectious brain lesion: 1 fusobacterial brain abscess, 1 neurosyphilis, and 1 tuberculous meningoencephalomyelitis. Thirty other neurologic diseases without focal brain lesions: 17 headache, 4 neurodegenerative disease, 2 epilepsy, 2 myasthenia gravis, 2 normal pressure hydrocephalus, and 3 idiopathic facial palsy