Fig. 3
From: The interplay between m6A RNA methylation and noncoding RNA in cancer
Regulation of lncRNAs by m6A modifications. Ι. XIST efficiently silences gene transcription by recruiting specific protein complexes to the X chromosome. XIST regulates the transcriptional silencing of genes by forming the (RBM15)/RBM15B-WTAP-METTL3 complex to recruit the silencing complex. Knocking down METTL3 or RBM15 reduces the level of m6A modifications, leading to impaired XIST-mediated gene silencing. II ALKBH5, as an m6A demethylase, interacts with the lncRNA FOXM1-AS to enhance its function. Then, ALKBH5 facilitates the binding of HuR to FOXM1 nascent transcripts. Ultimately, ALKBH5 induces a high level of FOXM1 by demethylating the 3′ UTRs of FOXM1 nascent transcripts