Fig. 5
From: The interplay between m6A RNA methylation and noncoding RNA in cancer
Regulation of m6A modifications by noncoding RNAs. Mature miR-145 and mRNAs are transported to the cytoplasm where they perform their respective roles. MiR-145 reduces the expression of YTHDF2 by targeting the 3′ UTR of YTHDF2 mRNA in HCC cells. Then, the reduction in YTHDF2 increases m6A mRNA levels, leading to decreases in the occurrence, proliferation, invasion, and metastasis of HCC cells. Taken together, the regulation of m6A modifications by miR-145 plays an important role in the biological function of HCC cells