Table 2 Tumor molecular markers with potential clinical value in HCC-related exosomes
From: Tumorigenesis, diagnosis, and therapeutic potential of exosomes in liver cancer
Factors as biomarker | Potential Mechanism | Exosome isolation methods | Ref |
|---|---|---|---|
circ-0008043, circ-0003731, circ-0088030↑ | Promote migration, invasion and metastasis | Exoquick (System Biosciences, USA) | [202] |
LINC00161↑ | Promote tumor migration and invasion | Total exosome isolation kit (Invitrogen, USA) | [196] |
LINC-000635, ENSG00000258332.1↑ | Positive related to portal vein tumor emboli, lymph node metastasis and worse OS | Total exosome isolation reagent (Thermo Fisher Scientific Co. Ltd, USA) | [199] |
lncRNA-FAL1↑ | Promote proliferation and migration | Exoquick TC (System Biosciences, USA) | [152] |
lncRNA-HEIH↑ | Promote tumor progression | GS0301 (Guangzhou Geneseed Biotech Co, China) | [198] |
lncRNA-RP11-513I15.6, mRNA-RAB11A↑, miR-1262↓ | Associate with poor prognosis | ExoRNeasy® RNA isolation kit (Qiagen, USA) | [201] |
miR-21↑ | Correlate with tumor stage | Total exosome isolation reagent (From serum) (Invitrogen, USA) | [17] |
miR-21↑, lncRNA-ATB↑ | Short progression time and OS | Exoquick (System Biosciences, USA) | [19] |
miR-155↑ | Promote tube formation under hypoxia condition | Exoquick (System Biosciences, USA) | [145] |
miR-93↑ | Stimulate proliferation and invasion | Total exosome isolation reagent (Thermo Fisher Scientific Co. Ltd, USA) | [151] |
miR-638↓ | Inhibit cancer cells proliferation | Total exosome isolation kit (Invitrogen, USA) | [174] |
miR-9-3p↓ | Suppress proliferation | Ultracentrifugation | [176] |
miR-92b↑ | Promote migration and affect NK cell cytotoxicity via downregulating CD69 | Exoquick (System Biosciences, USA) | [181] |
miR-718↓ | Suppresses cell proliferation via targeting HOXB8 | Ultracentrifugation | [182] |
miR-125b↓ | Short TTR and OS | Exoquick (System Biosciences, USA) | [194] |
mRNA-hnRNPH1↑ | Positive related to poor differentiation and worse OS | Total exosome isolation reagent (Thermo Fisher Scientific Co. Ltd, USA) | [175] |
G3BP↑, PIGR↑ | Promote tumor progression, transformation, invasion and proliferation | Ultracentrifugation | [206] |