Fig. 2
From: The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?
Mechanism of cell death during mitotic arrest. a MPF complex promotes the induction of apoptosis through direct phosphorylation of different pro-/anti-apoptotic factors. CDK1-mediated inactivating phosphorylation of the BCL2 and BCL-xL and activatory phosphorylation of the pro-apoptotic BIM. MPF complex also promotes the degradation of MCL-1 via APC/CCDC20. MCL1 loss promotes caspase activation leading to cell death [43,44,45]. b Graphic representation of the timing of reduction of Cyclin B1 level and the increment of pro-apoptotic signals in the contest of mitotic cell death. Rapid induction of pro-apoptotic signals in the presence of active MPF complex induces apoptosis during prolonged mitosis