Fig. 4
From: The balance between mitotic death and mitotic slippage in acute leukemia: a new therapeutic window?
Targeting mitosis using different mitotic inhibitors. Conventional mitotic poisons such as vincristine, vinblastine, or paclitaxel compromise cell proliferation interfering with microtubule assembly and affecting mitosis progression. Innovative selective inhibitors are available to selectively target mitosis in acute leukemia. MPF and CDC20 inhibitors compromise the early phase of mitosis and, in particular, the functionality of SAC complex enhancing mitotic cell death. Aurora kinase and PLK1 inhibitors dysregulate pre-mitotic and mitotic regulation and enhance the efficacy of chemotherapy agents or mitotic poisons