Skip to main content
Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Targeting cancers through TCR-peptide/MHC interactions

Fig. 2

Schematics of the methods used to prevent the mismatch between transduced TCRs and endogenous TCRs. (a) TCRs derived from MHC-transgenic mice. (b) Human TCRs variable region chimerized with murine TCRs constant region. (c) Human TCRs with an additional cysteine bridge at TCRs constant region. (d) Human TCRs with a knob-into-hole design at TCRs constant region. (e) Human TCRs chimerized with CD28 transmembrane and CD3ΞΆ intracellular domains. (f) Single-chain TCRs (scTCRs). (g) knockdown or knockout of endogenous TCRs by SiRNA, zinc finger nucleases (ZFN), transcription activator-like effector nucleases (TALENs), or by clustered regularly interspaced short palindromic repeats (CRISPR)

Back to article page