Fig. 1
From: Multi-antigen-targeted chimeric antigen receptor T cells for cancer therapy
“OR” logic-gated CAR-T cells for preventing tumor antigen escape. a Dual CAR-T cells: “OR” logic gate. Each CAR contains a complete signal domain that activates the antitumor effect of CAR-T cells in the presence of either cognate antigen. b Tandem CAR-T cells: “OR” logic gate. One CAR coexpresses two distinct antigen-binding domains in tandem, using the “OR” logic gate to activate T cell. c Trivalent CAR T cells: “OR” logic gate. Three CARs in one T cell utilize the “OR” logic gate to kill tumor cells in the presence of either validated antigen