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Table 1 EZH2 as epigenetic repressor in mediating T cell development

From: EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications

T cell subtypes



T follicular helper cell

Ezh2 deploys H3K27 tri-methylation to repress CDKN2A expression in Tfh cells, maintaining its differentiation and activation.

Li F., et al. [4]

T helper cell

EZH2 methylates H3K27 at the IL4-IL13 locus and represses IL4-IL13 expression in Th1 but not Th2 cells.

Koyanagi M., et al. [10]

T helper cell

SMAD2 and SMAD4 regulate TGF-β-mediated IL9 production via EZH2 displacement in Th9 cells.

Wang A., et al. [11]

T follicular regulatory cell

Ezh2 is required for Tfr suppressive function and transcriptional program.

Hou S., et al. [18]

Regulatory T cell

Treg cells from EZH2 −/− FOXP3+ mice display enhanced expression of target genes shared by EZH2 and FOXP3.

Sarmento OF., et al. [17]

Cytotoxic T cell and memory T cell

Terminal cytotoxic T cells display higher-level H3K27 tri-methylation than memory T cells and repression of memory T-specific genes.

Gray SM., et al. [5]

T helper cell

EZH2 keeps the correct expression of transcription factor TBX21 and GATA3 as well as cytokines like IFN-γ in Th1 and Th2 cells.

Tumes DJ., et al. [7]

Memory T cell

AKT-mediated EZH2 S21 phosphorylation attenuates EZH2 activity and enhances memory T cells to develop into T effector cells.

He S., et al. [6]

T helper cell, regulatory T cell

EZH2 epigenetically silence IFN-γ in Th2 and Treg, and IL10 in Th2. EZH2 deficiency accelerates Th cell death via apoptosis.

Zhang Y., et al. [12]

T helper cell, regulatory T cell

EZH2-deficient Th and Treg cells neither constrain T. gondii infection nor prevent autoimmune colitis.

Yang XP., et al. [15]

Regulatory T cell

Polycomb epigenetically silences FOXP3 in a KLF-dependent manner.

Xiong Y., et al. [8]

Regulatory T cell

EZH2 safeguards Treg identity by maintaining its transcriptome and thus prevents spontaneous autoimmunity.

DuPage M., et al. [16]

Regulatory T cell

FOXP3 poises its targets for repression by recruiting EZH2 upon Treg cells activation.

Arvey A., et al. [9]

NK T cell

EZH2 depletion disrupts the bivalent state at PRZF promoter and leads to the expression of non-NKT specific TCR.

Dobenecker MW., et al. [14]

Naïve CD8+ T cell

EZH2 promotes naïve CD8+ T cell proliferation by epigenetically repressing the expression of CDKN1C and CDKN2A.

Chen G., et al. [13]