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Table 1 EZH2 as epigenetic repressor in mediating T cell development

From: EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications

T cell subtypes Findings Authors
T follicular helper cell Ezh2 deploys H3K27 tri-methylation to repress CDKN2A expression in Tfh cells, maintaining its differentiation and activation. Li F., et al. [4]
T helper cell EZH2 methylates H3K27 at the IL4-IL13 locus and represses IL4-IL13 expression in Th1 but not Th2 cells. Koyanagi M., et al. [10]
T helper cell SMAD2 and SMAD4 regulate TGF-β-mediated IL9 production via EZH2 displacement in Th9 cells. Wang A., et al. [11]
T follicular regulatory cell Ezh2 is required for Tfr suppressive function and transcriptional program. Hou S., et al. [18]
Regulatory T cell Treg cells from EZH2 −/− FOXP3+ mice display enhanced expression of target genes shared by EZH2 and FOXP3. Sarmento OF., et al. [17]
Cytotoxic T cell and memory T cell Terminal cytotoxic T cells display higher-level H3K27 tri-methylation than memory T cells and repression of memory T-specific genes. Gray SM., et al. [5]
T helper cell EZH2 keeps the correct expression of transcription factor TBX21 and GATA3 as well as cytokines like IFN-γ in Th1 and Th2 cells. Tumes DJ., et al. [7]
Memory T cell AKT-mediated EZH2 S21 phosphorylation attenuates EZH2 activity and enhances memory T cells to develop into T effector cells. He S., et al. [6]
T helper cell, regulatory T cell EZH2 epigenetically silence IFN-γ in Th2 and Treg, and IL10 in Th2. EZH2 deficiency accelerates Th cell death via apoptosis. Zhang Y., et al. [12]
T helper cell, regulatory T cell EZH2-deficient Th and Treg cells neither constrain T. gondii infection nor prevent autoimmune colitis. Yang XP., et al. [15]
Regulatory T cell Polycomb epigenetically silences FOXP3 in a KLF-dependent manner. Xiong Y., et al. [8]
Regulatory T cell EZH2 safeguards Treg identity by maintaining its transcriptome and thus prevents spontaneous autoimmunity. DuPage M., et al. [16]
Regulatory T cell FOXP3 poises its targets for repression by recruiting EZH2 upon Treg cells activation. Arvey A., et al. [9]
NK T cell EZH2 depletion disrupts the bivalent state at PRZF promoter and leads to the expression of non-NKT specific TCR. Dobenecker MW., et al. [14]
Naïve CD8+ T cell EZH2 promotes naïve CD8+ T cell proliferation by epigenetically repressing the expression of CDKN1C and CDKN2A. Chen G., et al. [13]