Skip to main content
Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Preclinical efficacy for a novel tyrosine kinase inhibitor, ArQule 531 against acute myeloid leukemia

Fig. 1

ARQ 531 demonstrates in vitro anti-leukemic effect. MTS proliferation assay for 72 h from three independent experiments using increasing concentrations of ARQ 531 treatment in MOLM-13, MV4-11, OCI-AML3, U937, and THP-1 AML cell lines (a). Representative of three replicates for Annexin-V/PI apoptosis assay for 72 h treatment of increasing concentrations of ARQ 531 or 50 nM of gilteritinib (Gilt.) in MOLM-13 (b), MV4-11 (c), and OCI-AML3 (d) cell lines. MTT proliferation assay for 72 h from two independent experiments using increasing of increasing concentrations of ARQ 531 in MOLM-13-resistant (MOLM13 Res) cell line (e) and Ba/F3 murine pro B cell line with FLT3-ITD or TKD or both FLT3-ITD-TKD mutations (f). **p ≤ 0.001

Back to article page