Fig. 3
From: Clinical correlates of blood-derived circulating tumor DNA in pancreatic cancer
A representative PDAC case who underwent a matched targeted therapy based on ctDNA analysis. An 83-year-old man treated with the MEK inhibitor trametinib as single-agent therapy [ID#111]; he had alterations in GNAS, KRAS, and NF1, all of which can activate the MEK pathway. The patient showed improvement in symptoms, CA19-9, and %ctDNA in the altered genes. CT scans with contrast could not be performed due to renal insufficiency. Treatment is ongoing at 26+ weeks