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Fig. 5 | Journal of Hematology & Oncology

Fig. 5

From: Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma

Fig. 5

Nano-com exhibits a synergistic cytotoxic effect in HNSCC cells by co-inactivating Src and AKT signaling. a Schematic illustration of the self-assemble Nano-com and its disassembly upon CTSB digestion. b The Z-average of single and dual drug-loaded nanoscale formulations determined by DLS. c The drug release profile of Nano-com at various conditions determined by HPLC. d The effects of single and dual drug-loaded NPs on the Src and AKT activation in HN12 cells determined by Western blotting. e The effects of single and dual drug-loaded NPs and the free drug combination on HN12 cell colony formation on day 7 after treatment. f The effects of single and dual drug-loaded NPs and the free drug combination on 3D cell growth on day 12 after treatment. Nano-sar: saracitinib-loaded NPs; Nano-cap: capivasertib-loaded NPs; Com: free saracatinib/capivasertib combination; Nano-com: the saracatinib/capivasertib co-delivery NPs. *p < 0.05; **p < 0.01

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