Fig. 7

Nano-com improves the anti-HNSCC effect by co-inhibiting Src and AKT signaling in orthotopic xenograft mice. a, b The levels of phospho-Src, phospho-S6 and Ki67 in orthotopic xenograft tumors receiving different treatments determined by IHC. The representative IHC images were shown in (a) and quantification of IHC staining using Image pro-Plus6.0 was shown in (b). c, d The levels of apoptosis in orthotopic xenograft tumors receiving different treatments determined by TUNEL assays. The representative TUNEL-stained xenograft sections were shown in (c) and quantification of TUNEL-positive tumor cells was shown in (d). Nano-sar: saracitinib-loaded NPs; Nano-cap: capivasertib-loaded NPs; Com: free saracatinib/capivasertib combination; Nano-com: the saracatinib/capivasertib co-delivery NPs. *p < 0.05; **p < 0.01