Table 1 Comparison between PDX models and organoids
From: Applications of patient-derived tumor xenograft models and tumor organoids
PDX | Organoids | |
|---|---|---|
Genetic/epigenetic alterations | Similar | Similar |
Pathohistological characteristics | Similar | Similar |
Response to anti-cancer drugs | Similar | Similar |
Use of immunodeficient animals | Yes | No |
Reliability as pre-clinical models | Yes | Yes |
Quantity of cells for establishment | Large | Small |