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Table 1 Patient’s demographics and tumor characteristics and association of METTL3 levels with clinicopathological features

From: RETRACTED ARTICLE: m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

Characteristics

No. of patients, N = 50 (%)

P value

Patients’ parameter

  

 Age (years)

 

0.542

 Average [range]

55 [30-81]

 

  <55

14 (28.0)

 

  ≥55

36 (72.0)

 

Gender

 

0.881

 Male

29 (58.0)

 

 Female

21 (42.0)

 

Tumor characteristics

  

 Tumor size (cm)

 

0.002**

  <4

7 (14.0)

 

  ≥4

43 (86.0)

 

 Differentiation

 

0.076

  Poor

33 (66.0)

 

  Well-moderate

17 (34.0)

 

 Lymph node metastasis

0.024*

  N−

7 (14.0)

 

  N+

43 (86.0)

 

 Distant metastasis

 

0.011*

  M−

11 (22.0)

 

  M+

39 (78.0)

 

Expression of METTL3

  

 Protein level

  

  High

35 (70.0)

0.002**

  Median

10 (20.0)

0.071

  Low

5 (10.0)

0.332

 mRNA level

  

  High

36 (72.0)

0.003**

  Median

9 (18.0)

0.083

  Low

5 (10.0)

0.532

  1. Differences between experimental groups were assessed by Student’s t test or one-way analysis of variance. Data represent mean ± SD
  2. *p < 0.05; **p < 0.01