From: Emerging organoid models: leaping forward in cancer research
Feature | PDTX models | Cancer organoids |
---|---|---|
Generation efficiency | 70%–100% | |
Tumor tissue source | Surgically resected specimens | Surgically resected or biopsy needle specimens |
Retention of heterogeneity | Retention | Retention |
Generation time | 4–8 months | |
Passage efficiency | Low | High |
Genetic manipulation | Not amenable | Amenable |
High-throughput screening for drug discovery | No | Yes |
Immune components | Without | |
Cost | High | Low |