Table 3 The miRNAs regulating PD-L1 expression on cancer cells
From: The role of cancer-derived microRNAs in cancer immune escape
miRNAs | Effects of miRNA on PD-L1 expression | Cancer cell types | Ref. |
|---|---|---|---|
miR-195-5p | Downregulating | Pancreatic cancer | [87] |
Downregulating | Colon adenocarcinoma | [91] | |
Downregulating | Prostate cancer | [98] | |
Downregulating | DLBCL | [99] | |
miR-3609 | Downregulating | Breast cancer | [86] |
miR-148a-3p | Downregulating | Colorectal cancer | [88] |
miR-873 | Downregulating | Breast cancer | [89] |
miR-146a | Upregulating | Melanoma | [100] |
miR-497-5p | Downregulating | Clear cell renal cell carcinoma | [90] |
miR-16 | Downregulating | Prostate cancer | [98] |
Downregulating | MPM | [96] | |
miR-34a | Downregulating | B cell lymphomas | [92] |
Downregulating | Glioma | [93] | |
Downregulating | AML | ||
miR-140 | Downregulating | Cervical cancer | [95] |
Downregulating | NSCLC | [103] | |
miR-142 | Downregulating | Cervical cancer | [95] |
Downregulating | NSCLC | [104] | |
Downregulating | Pancreatic cancer | [105] | |
miR-340 | Downregulating | Cervical cancer | [95] |
miR-383 | Downregulating | Cervical cancer | [95] |
miR-18a | Upregulating | Cervical cancer | [95] |
miR-3127-5p | Upregulating | NSCLC | [97] |
miR-200 family | Downregulating | Lung cancer | [106] |
Downregulating | Hepatocellular carcinoma | [107] | |
Downregulating | AML | [101] | |
miR-375 | Downregulating | HNSCC | [108] |
miR-138 | Downregulating | Colorectal cancer | [94] |
Downregulating | Colorectal cancer | [109] | |
miR-15a | Downregulating | MPM | [96] |
miR-193a-3p | Downregulating | MPM | [96] |
miR-93 | Downregulating | Pancreatic cancer | [110] |
miR-106b | Downregulating | Pancreatic cancer | [110] |
miR-17-5p | Downregulating | Melanoma | [111] |
miR-197 | Downregulating | NSCLC | [112] |