Fig. 6From: Long non-coding RNA HUMT hypomethylation promotes lymphangiogenesis and metastasis via activating FOXK1 transcription in triple-negative breast cancerHUMT promotes cell proliferation and metastasis in vivo. a Representative picture of the subcutaneous graft model in nude mice using corresponding modulated 231LNM3 cells. b Tumor weight after implantation of corresponding cells. c, d The representative picture (231LNM3) and the corresponding volume of lymph nodes in different groups. e Representative picture of immunohistochemical staining of lymph nodes in different groups. f The metastatic ratio of lymph nodes in different groups. g Representative picture of metastatic mice lung, bioluminescence, and HE staining in different groups. h Quantification of metastatic lung nodules. i HUMT and FOXK1 expression in tumors were examined by qRT-PCR. j, k Tumor growth volume and tumor weights in two PDX models of intratumoral treatment with ASO-HUMT and NC. Data were shown as mean ± SD; **P < 0.01Back to article page