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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Expression patterns of immune checkpoints in acute myeloid leukemia

Fig. 1

Overall survival (OS) of ICs in AML patients. a The OS probability in AML patients with high or low PD-1, PD-L1, or PD-L2 expression in TCGA group. (left panel) X-tile software (version 3.6.1) was used to define the optimal cutoff value for gene expression levels for prognosis, which is represented by the highest intensity pixel. Black dots represent the optimal cutoff value. The black to red or green in the color scale indicates that the range of pixels was from low to high. (right panel) Kaplan–Meier curves based on the optimal cutoff values. b The OS probability in AML patients with high or low PD-1, PD-L1, or PD-L2 expression in the validation group (n = 62). c Relationship between PD-1, PD-L1, and PD-L2 and other immune checkpoints in TCGA group. The outermost circle indicates 1 to 22, X and Y chromosomes; the second layer shows the location of the genes in the chromosomes; the third layer shows the IC genes; the innermost layer represents the average expression levels of the genes, which is shown by the height of the column; the lines in the center of the circle show the co-expression network of the PD-1, PD-L1, and PD-L2 and other ICs. The red font in the center of the circle displays the Pearson’s coefficient with a P value < 0.05 for the correlation of two IC genes. d, f The OS probability in AML patients with high or low CTLA-4 and LAG-3 based on the optimal cutoff values provided by the X-tile software (version 3.6.1) in TCGA group (d) and in the validation group (f). e The chord diagram shows the co-expression network between PD-1, PD-L1, PD-L2, CTLA-4, and LAG-3 in BM samples from AML patients in the validation group (n = 62). The band represents a positive correlation between the two IC genes, and the thickness indicates the magnitude of the Pearson’s correlation coefficient (the P value for testing the correlation coefficient was < 0.05)

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