Fig. 1
Cross-talk identified among the m6A and 5mC regulators. a m6A and 5mC regulator genes and a diagram of their potential cross-talk. b Correlations between the expression of m6A and 5mC regulators. The scatter plot shows the strong positive correlation between YTHDC1 and TET2. The Pearson correlation coefficients (R) are shown. c Co-occurrence of genetic alterations in m6A and 5mC regulators. The log2 (odds ratio) is colored as a heat map. The Nightingale rose diagram shows the mutation frequency distribution of m6A and 5mC regulators across different cancer types. d Protein-protein interactions among the m6A and 5mC regulators based on the GeneMANIA database