Fig. 2
Development and characterization of the m6A/5mC epigenetic module eigengenes (EMEs). a Module membership-based hub m6A and 5mC regulators across 33 cancer types. The lower panel shows the number of hub m6A and 5mC regulators in each cancer type. b Correlations between the number of hub m6A regulators and the number of hub 5mC regulators. The Pearson correlation coefficients (R) are shown. c Gene set enrichment analysis (GSEA) results (normalized enrichment scores [NES] and q values) regarding the hallmark oncogenic pathways for EMEhigh versus EMElow subgroups across 33 cancer types. Enrichment score terms with an FDR < 0.05 are shown. d Heatmap showing the Pearson correlation coefficients between the EMEs and immuno-stromal signatures across 30 cancer types. Diffuse large B cell lymphoma (DLBC), acute myeloid leukemia (LAML), and thymoma (THYM) were excluded, as they mainly consist of immune cells