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Fig. 2 | Journal of Hematology & Oncology

Fig. 2

From: Bispecific CAR-T cells targeting both CD19 and CD22 for therapy of adults with relapsed or refractory B cell acute lymphoblastic leukemia

Fig. 2

Expansion and persistence of bispecific CAR T cells and tumor response in patients treated with bispecific CAR T cells. a Treatment response of each patient after bispecific CAR T cell treatment and the duration of response. Ongoing remission is marked by a black arrow. Patient number is shown to the left. b The presence of CD19/CD22 CAR T cells in the peripheral blood as assessed by quantitative real-time polymerase chain reaction (PCR) assay. Genomic DNA was isolated from samples of whole blood samples collected at serial time points before and after cell infusion. of the y axis. c The results of flow cytometry analysis showing in vivo expansion of bispecific CAR T cells in the peripheral blood and bone marrow of representative patient 5, who achieved a MRD negative. Both the x and y axes are log10 scales. MRD, minimal residual disease

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