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Fig. 1 | Journal of Hematology & Oncology

Fig. 1

From: Vasculogenic mimicry in carcinogenesis and clinical applications

Fig. 1

Different forms of tumor angiogenesis. aVasculogenesis: recruiting endothelial progenitor cell (EPC) to participate in the formation of tumor blood vessels. b Sprouting angiogenesis: the sprouting of new blood vessels from the existing vasculature. c Intussusceptive angiogenesis: the splitting of pre-existing vessel to give rise to daughter vessels. d Vessel co-option: hijacking the existing vasculature and tumor cells migrate along the existing or newly induced blood vessels. e, f Vasculogenic mimicry: does not depend on endothelial cells, VM of tubular type are lined by EC-like tumor cells and covered by secretory glycoprotein, and the patterned matrix type is covered by the PAS-positive matrix.

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