Table 1 MiRNAs in VM
From: Vasculogenic mimicry in carcinogenesis and clinical applications
MiRNA | Cancer type | Target | Function characteristic | Effect of VM formation | Reference |
|---|---|---|---|---|---|
miRNA-27b | Ovarian cancer | VE-cadherin | inhibits ovarian cancer cell migration and VM via binding to the 3′-untranslated region(3′UTR) of VE-cadherin mRNA | Suppress | [98] |
miRNA-584-3P | Glioma | ROCK1 | Disturbs hypoxia-induced ROCK1-dependent stress fiber formation | Suppress | [87] |
MiRNA-let-7f | Glioma | POSTN | Disturbs the POSTN-dependent migration | Suppress | [86] |
miR141 | Glioma | EphA2 | Inhibits EphA2 expression | Suppress | [88] |
miR-27a-3p | Hepatocellular carcinoma | VE-cadherin | Targets the 3′-UTR of VE-cadherin, and suppresses EMT signaling | Suppress | [92] |
miR-193b | Breast cancer | DDAH1 | Regulates MDA-MB-231 cells migration and VM formation via targeting DDAH1 | Suppress | [97] |
miR-125a/let-7e | Breast cancer | IL-6, IL-6R, STAT3 | Suppresses IL-6-induced adhesion of monocytes to ECs and VM formation | Suppress | [96] |
miR-200a | Ovarian cancer | EphA2 | Inhibits EphA2 expression | Suppress | [99] |
miR-490-3p | Clear cell renal cell carcinoma | Vimentin | - | Suppress | [28] |
miR-745 | Ovarian cancer | VEGFR/AKT1/SRC-α | Decreases the levels of VEGFA, AKT1, and SRC-α transducers and exerts a negative regulation of VEGFA by specific binding to its 3'UTR | Suppress | [74] |
miR-9 | Glioma | Stathmin (STMN1) | targets the 3′-UTR of STMN1 | Suppress | [75] |
miR-186 | Prostate cancer | Twist1 | - | Suppress | [84] |
miR-101 | Hepatocellular carcinoma | TGF-β1, Smad2 | Targets TGF-ΒR1 and Smad2 to attenuate TGF-β signaling transduction in tumor cells and blocks SDF1 signaling | Suppress | [93] |
miR-124 | Cervical cancer | Amotl1 | Represses VM, migration, and invasion in HeLa and C33A cells by regulating AmotL1’s 3'untranslated region (3'UTR) | Suppress | [85] |