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Table 1 Anti-proliferative activity of MI130110 in CD13-positive and negative cell lines. Values represent the geometric mean of three or more different experiments, each performed in triplicate

From: CD13 as a new tumor target for antibody-drug conjugates: validation with the conjugate MI130110

Tumor cell line

Cancer type

CD13 status

IC50 (μg/mL)

GSD

HT1080

Fibrosarcoma

Positive

0.17

1.32

NB-4

Leukemia

Positive

0.10

3.5

U-937

Lymphoma

Positive

0.14

3.3

RPMI 8226

Myeloma

Negative

> 1.0

-

Raji

Lymphoma

Negative

> 1.0

-

  1. . IC50 concentration that inhibits cell growth by 50%, GSD geometric standard deviation