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Fig. 2. | Journal of Hematology & Oncology

Fig. 2.

From: m6A-binding proteins: the emerging crucial performers in epigenetics

Fig. 2.

The regulation of m6A modification. m6A is established by m6A methyltransferases (“writers”) and removed by m6A demethylases (“erasers”). m6A readers are involved in multiple procedures of RNA metabolism through recognizing and binding to the m6A sites of RNAs. (a) HNRNPC plays an important role in the pre-mRNAs processing and structure switching. (b) HNRNPG modulates alternative splicing and structure switching. (c) HNRNPA2B1 accelerates primary miRNAs processing, alternative splicing, and structure switching. (d) YTHDC1 participates in the alternative splicing, nuclear export, and X chromosome silencing. (e) IGF2BP1/2/3 have a function to increase the stability of targeted mRNAs. (f) YTHDC2 promotes mRNAs translation. (g) YTHDF1 augments mRNAs translation. (h) YTHDF2 facilitates mRNAs decay. (i) YTHDF3 cooperates with YTHDF1 to increase mRNAs translation, and strengthens mRNAs decay mediated by YTHDF2

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