Fig. 3From: Participation of the ATR/CHK1 pathway in replicative stress targeted therapy of high-grade ovarian cancerThe role of PARP inhibitors in cancer therapy. PARP inhibitors are effective in HR-deficient cancer cells by the mechanism of synthetic lethality (left panel) and by PARP trapping (right panel). Other mechanisms of PARPi action are described in the textBack to article page