From: How to select IgG subclasses in developing anti-tumor therapeutic antibodies
Targets | Proposed IgG |
---|---|
PD-1xTIM-3 | IgG4 |
PD-1xLAG-3 | IgG4 |
PD-1x4-1BB | IgG4, Fc engineering for FcγRIIB engagement |
PD-1xCD40 | IgG4, Fc engineering for FcγRIIB engagement |
PD-1xOX40 | IgG4, Fc engineering for FcγRIIB engagement |
PD-1xNKG2A | IgG4 |
PD-1xSIRPa | IgG4 |
PD-L1xCTLA-4 | IgG1, Fc engineering for FcγRIIA/FcγRIIIA engagement |
CTLA-4xGITR | IgG1, Fc engineering for FcγRIIA/FcγRIIIA engagement |
CTLA-4xCSF1R | IgG1, Fc engineering for FcγRIIA/FcγRIIIA engagement |
PD-L1xCD47 | IgG1, Fc engineering for FcγRIIA/FcγRIIIA engagement |
CD3xTarget2 | IgG4, KIH format |