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Table 5 Proposed IgG subclass for selected target pairs

From: How to select IgG subclasses in developing anti-tumor therapeutic antibodies

Targets

Proposed IgG

PD-1xTIM-3

IgG4

PD-1xLAG-3

IgG4

PD-1x4-1BB

IgG4, Fc engineering for FcγRIIB engagement

PD-1xCD40

IgG4, Fc engineering for FcγRIIB engagement

PD-1xOX40

IgG4, Fc engineering for FcγRIIB engagement

PD-1xNKG2A

IgG4

PD-1xSIRPa

IgG4

PD-L1xCTLA-4

IgG1, Fc engineering for FcγRIIA/FcγRIIIA engagement

CTLA-4xGITR

IgG1, Fc engineering for FcγRIIA/FcγRIIIA engagement

CTLA-4xCSF1R

IgG1, Fc engineering for FcγRIIA/FcγRIIIA engagement

PD-L1xCD47

IgG1, Fc engineering for FcγRIIA/FcγRIIIA engagement

CD3xTarget2

IgG4, KIH format