DNA methylation aberration of ACE2 in tumors. a Probes for detecting DNA methylation of ACE2 promoter. b Four highly ACE2 express tumors presented with decreased DNA methylation level of ACE2, including colon adenocarcinoma (COAD), kidney renal papillary cell carcinoma (KIRP), pancreatic adenocarcinoma (PAAD), and rectum adenocarcinoma (READ). *p < 0.05. This data was obtained using Ualcan. c An ACE2 downregulated tumor, testicular germ cell tumors (TGCT), presented increased DNA methylation level. *p < 0.05. This data was obtained using Ualcan.