From: Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment
Non-coding RNA | Cancer type | Exosome isolation method | NcRNA identification method | Donor cell | Recipient cell | Function | Mechanism | Ref. |
---|---|---|---|---|---|---|---|---|
miR-21 | glioma | ultracentrifugation | RNA-sequencing | cancer cell | MDSC | promote MDSC expansion and activation | regulating PTEN/PI3K/AKT axis | [81] |
oral squamous cell carcinoma | commercial kit | RNA-sequencing | cancer cell | γδT-cell | stimulate γδT-cell expansion and function | inducing PD-L1 expression though targeting PTEN | [82] | |
oral squamous cell carcinoma | commercial kit | qRT-PCR | cancer cell | cancer cell | promote migration and invasion | inducing EMT | [72] | |
lung cancer | ultracentrifugation | qRT-PCR | cancer cell | cancer cell | promote chemoresistance | downregulating PTEN and PI3K/ATK pathway | [83] | |
miR-21-3p | ovarian cancer | commercial kit | miRNA microarray | cancer cell | macrophage | induce M2 polarization | regulating SOCS4/5/STAT3 pathway | [84] |
miR-210 | leukemia | commercial kit | miRNA microarray | cancer cell | endothelial cell | promote angiogenesis | NA | [37] |
breast cancer | ultracentrifugation& commercial kit | qRT-PCR | cancer stem cell | cancer cell | promote proliferation, Invasion and self-renewal ability | targeting E-cadherin | ||
lung cancer | commercial kit | miRNA microarray | BMSC | cancer cell | promote metastasis | inducing STAT3 driven EMT | [86] | |
miR-23a | liver cancer | ultracentrifugation | qRT-PCR | cancer cell | endothelial cell | promote angiogenesis | targeting SIRT-1 | [97] |
lung cancer | commercial kit | qRT-PCR | cancer cell | endothelial cell | promote angiogenesis and increase vascular permeability | inhibiting PHD1 and PHD2 expression, thus enhancing HIF-1α signaling and inhibiting tight junction protein ZO-1 | [71] | |
lung cancer | ultracentrifugation | miRNA microarray | cancer cell | NK cell | impair NK cell cytotoxicity and NK cell function | targeting CD107a | [35] | |
lncRNA UCA1 | bladder cancer | commercial kit | qRT-PCR | cancer cell | cancer cell | promote migration and invasion, increase tumor growth and progression | inducing EMT | [73] |
miR-25-3p | breast cancer | commercial kit | qRT-PCR | cancer cell | cancer cell ¯ophage | promote proliferation and migration | stimulating IL-6 secretion from macrophages via NF-κB pathway | [88] |
miR10a | glioma | ultracentrifugation | RNA-sequencing | cancer cell | MDSC | promote MDSC expansion and activation | regulating RORA/IκBα/NF-κB axis | [81] |
miR-1273f | hepatocellular carcinoma | ultracentrifugation | qRT-PCR | cancer cell | cancer cell | promote proliferation | inhibiting LHX6/Wnt/β-catenin pathway | [89] |
linc-RoR | hepatocellular carcinoma | commercial kit | qRT-PCR | cancer cell | cancer cell | promote proliferation and increase chemoresistance | Inducing phosphorylation of p70S6K1 (RPS6KB1), PDK1 and HIF-1α protein expression and decreasing miR-145 | |
miR-193a-3p | lung cancer | commercial kit | miRNA microarray | BMSC | cancer cell | promote metastasis | inducing STAT3 driven EMT | [86] |
miR-5100 | lung cancer | commercial kit | miRNA microarray | BMSC | cancer cell | promote metastasis | inducing STAT3 driven EMT | [86] |
miR-494 | lung cancer | ultracentrifugation | qRT-PCR | cancer cell | endothelial cell | promote angiogenesis | downregulating PTEN and activating Akt/eNOS pathway | [92] |
let7a | melanoma | ultracentrifugation | qRT-PCR | cancer cell | macrophage | induce M2 polarization of infiltrating myeloid cells and enhance mitochondrial OXPHOS | downregulating insulin-AKT-mTOR signaling pathway | [93] |
miR-135b | multiple myeloma | commercial kit | miRNA microarray | cancer cell | endothelial cell | promote angiogenesis | targeting FIH | [94] |
miR-24-3p | nasopharyngeal carcinoma | ultracentrifugation | miRNA Microarray | cancer cell | T-cell | inhibit T cell proliferation and differentiation | repressing FGF11, up-regulating p-ERK, p-STAT1, p-STA3, down-regulating p-STAT5 | [95] |
miR-125b-5p | ovarian cancer | commercial kit | miRNA Microarray | cancer cell | macrophage | induce M2 polarization | regulating SOCS4/5/STAT3 pathway | [84] |
miR-181d-5p | ovarian cancer | commercial kit | miRNA Microarray | cancer cell | macrophage | induce M2 polarization | regulating SOCS4/5/STAT3 pathway | [84] |
miR-940 | ovarian cancer | commercial kit | qRT-PCR | cancer cell | macrophage | induce M2 polarization of MDSC | NA | [36] |
miR-223 | ovarian cancer | commercial kit | qRT-PCR | macrophage | cancer cell | promote drug resistance | inactivating PI3K/AKT pathway through targeting PTEN | [96] |
miR-301a-3p | pancreatic cancer | commercial kit | qRT-PCR | cancer cell | macrophage | induce M2 polarization | downregulating PTEN expression and activating PI3Kγ signaling pathway | [97] |