Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

Table 2 Hypoxic tumor-derived circulating exosomal non-coding RNAs as diagnostic and prognostic biomarkers

Cancer type	Sample type	Sample size	Sample grouping	Non-coding RNA	Expression	Clinical significance	Ref.
locally advanced rectal cancer	plasma	24	cancer patients and healthy donors	miR-486-5p	downregulated	associated with organ-invasive primary tumor and lymph node metastasis	[123]
				miR-181a-5p	downregulated	associated with organ-invasive primary tumor and lymph node metastasis
				miR-30d-5p	upregulated	associated with metastatic progression
ovarian cancer	serum	12	recurrence patients and primary patients	miR-223	upregulated	associated with recurrence	[96]
nasopharyngeal carcinoma	plasma	85	cancer patients and healthy donors	miR-24-3p	upregulated	negatively associated with DFS	[95]
lung cancer	serum	30	cancer patients and healthy donors	miR-23a	upregulated	diagnostic marker	[71]
OSCC	serum	216	cancer patients and healthy donors	miR-21	upregulated	associated with T stage, and N stage	[72]
Bladder cancer	serum	60	cancer patients and healthy donors	lncRNA-UCA1	upregulated	diagnostic marker	[73]

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