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Table 2 Hypoxic tumor-derived circulating exosomal non-coding RNAs as diagnostic and prognostic biomarkers

From: Non-coding RNAs shuttled via exosomes reshape the hypoxic tumor microenvironment

Cancer type Sample type Sample size Sample grouping Non-coding RNA Expression Clinical significance Ref.
locally advanced rectal cancer plasma 24 cancer patients and healthy donors miR-486-5p downregulated associated with organ-invasive primary tumor and lymph node metastasis [123]
miR-181a-5p downregulated associated with organ-invasive primary tumor and lymph node metastasis
miR-30d-5p upregulated associated with metastatic progression
ovarian cancer serum 12 recurrence patients and primary patients miR-223 upregulated associated with recurrence [96]
nasopharyngeal carcinoma plasma 85 cancer patients and healthy donors miR-24-3p upregulated negatively associated with DFS [95]
lung cancer serum 30 cancer patients and healthy donors miR-23a upregulated diagnostic marker [71]
OSCC serum 216 cancer patients and healthy donors miR-21 upregulated associated with T stage, and N stage [72]
Bladder cancer serum 60 cancer patients and healthy donors lncRNA-UCA1 upregulated diagnostic marker [73]